URGENT

*** JOURNAL OF ***

Please read this proof carefully for printers' errors, and check the tables, figures, Iegends and any mathematical or other scientifrc expressions. Extensive alterations should not be made. Changes in proof cause delay and considerable expense and the Publishers reserve the right to charge for excessive alterations made at proof stage. Queries for authors are marked on the proof and must be answered clearly by the author. Please make all marks in red. Please keep one copy of the proof for your own records.

It is particularly important that references to drug dosage and all other quantitative information appearing in the proof should be checked most carefully to avoid the publication of misleading data.

The proof should be returned within 48 hours to: *** Journal of *** Production Office, Scientific and Medical Division, The Macmillan Press Ltd, Houndmills, Basingstoke, Hampshire *** , UK. If from overseas, it should be sent by AIRMAIL or COURIER or by FAX (+44 256 ****).

The copyright assignment form should bc completed and returned to the publisher's office, by AIRMAIL if from overseas.

OFFPRINTS

A total of 25 free offprints of each article will be supplied to authors automatically after publication. Should additional offprints bc required, please indicate on the offprint order form and return it to the publisher's office, by AIRMAIL or FAX (+44 256 ****) if from overseas. The charges are necessarily higher if orders are received after the issue has gone to press.