Editorial

Dear Dr. ***

Re: Manuscript No. ***

Thank you for your letter dated 21 April 199*, and please find enclosed a revised version of our manuscript with a copy. The answers to the comments raised by the referees are on attached separate pages.

I look forward to your favorable consideration.

Sincerely yours,

Answers to the comments by Referee 1.

Thank you for your comments which will improve our manuscript.

The referee requested to add discussion about the relationship between the potassium signal and changes in calcium concentration when baseline calcium shifts or the oscillations are very fast. In the Discussion (p5, l9), we tried to answer this.

Minor points:

1. The A23187 experiments should not be mentioned in the abstract . . . .

Deleted from the abstract.

2. There are several referencing problems.

Corrected (p3, p11, p8) .

3. It must be possible to asses the modulation of FCCP in a more quantitative way . . . .

The pattern of modulation is difficult to asses quantitatively. But we added quantitative data on the point in p6, l11.

4. . . change the title of the paper . . . .

We changed the title as you mentioned.

5. . . . should adapt the last line of the discussion . . . .

We modified the sentence according to the suggestion by the referee 2. We think this discussion is not so inadequate.

Answers to the comments by Referee 2.

Thank you for your comments and correction.

We corrected the grammatical errors those you have kindly indicated.