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On behalf of the Editorial Board we wish to inform you that this paper has been accepted for publication in the Journal. Your paper has now been sent to the publisher and the date of acceptance will be the date of receipt by the publisher. You can expect to receive proofs in 4-5 weeks time.
This is an interesting and potentially important paper showing that adenine has pharmacological effects in rat megakaryocytes. As adenine has been thought until now to be inactive these results are novel and could open up a new area of research. I have no scientific criticisms of the paper, which is generally well-presented and very convincing, but the English is somewhat unidiomatic in places and does need a little attention.

As a report of preliminary data I can see no scientific reasons to fault the work presented in this manuscript. Indeed these data make an interesting contribution to the field of purinoceptor pharmacology by showing that adenine, a compound which was previously thought to be pharmacologically inactive, is able to potentiate the effects of ATP at P2-purinoceptors. However, I do feel that the general standard of the written English in the manuscript is really quite poor making it quite difficult to follow in a number of places. Whilst I feel that bad grammar is not a suitable reason, on its own, for rejection of the manuscript these grammatical errors must be addressed before it can be viewed as suitable for publication. I wou]d point out here that one of the assessment criteria given for referees by the Journal is that manuseripts "must be clearly and concisely written in good English... . ''